Magnusson L, Rebagliati M, Buchser E
Service d'Anesthésiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, CH.
Can J Anaesth. 1993 Jul;40(7):596-600. doi: 10.1007/BF03009694.
The aim of this study was to evaluate the effectiveness of captopril for the prevention of the increase of arterial pressure during orthopaedic surgery requiring the application of lower limb tourniquets with balanced anaesthesia. Twenty consecutive patients were included in the study and were randomly divided into two groups. The first (n = 10) received 50 mg captopril orally together with the preanaesthetic medication, the second (n = 10) received a placebo at the same time. The different variables studied (arterial pressure, heart rate) were continuously measured. This study demonstrated that the pretreatment with captopril did not prevent an increase of the arterial pressure during the application of a tourniquet. The means of the systolic and diastolic arterial pressures at the end of the application of the tourniquet were 128/86 and 128/81 in the captopril group and the placebo group, respectively. This result shows that the renin-angiotensin system does not significantly contribute to the increase of the arterial pressure induced by a tourniquet.
本研究的目的是评估卡托普利在平衡麻醉下应用下肢止血带的骨科手术中预防动脉压升高的有效性。连续20例患者纳入本研究，并随机分为两组。第一组（n = 10）在麻醉前用药时口服50 mg卡托普利，第二组（n = 10）同时服用安慰剂。连续测量所研究的不同变量（动脉压、心率）。本研究表明，卡托普利预处理不能预防止血带应用期间动脉压的升高。卡托普利组和安慰剂组在止血带应用结束时收缩压和舒张压的平均值分别为128/86和128/81。该结果表明，肾素-血管紧张素系统对止血带引起的动脉压升高没有显著作用。
