Greven J, Klein H
Naunyn Schmiedebergs Arch Pharmacol. 1977 Feb;296(3):289-92. doi: 10.1007/BF00498695.
The renal effects of dopamine were studied using clearance and micropuncture techniques in rats. Intravenous infusion of dopamine (4.7 - 10(-6) mol - kg-1 - h-1) increased glomerular filtration rate and renal blood flow. Renal blood flow was measured by an electromagnetic flowmeter. The increase in filtered fluid and sodium was nearly completely matched by increased tubular reabsorption. Thus, only a small rise in urine flow and in urinary sodium excretion was observed. The micropuncture experiments using the split oil droplet method of Gertz demonstrated a stimulation of the transepithelial fluid transfer after injection of dopamine (10(-4) M) into the proximal tubular lumen. This effect was abolished by simultaneous injection of propranolol (10(-3) M) which, by its own, did not affect transtubular volume fluxes. It is concluded that dopamine, by stimulation of beta-adrenoceptors, may increase reabsorptive capacity of the proximal tubular epithelium independent of changes in renal hemodynamics.
采用清除率和微穿刺技术在大鼠身上研究了多巴胺对肾脏的影响。静脉输注多巴胺（4.7×10⁻⁶ 摩尔·千克⁻¹·小时⁻¹）可增加肾小球滤过率和肾血流量。肾血流量通过电磁流量计测量。滤过液和钠的增加几乎完全与肾小管重吸收的增加相匹配。因此，仅观察到尿流量和尿钠排泄量有小幅增加。使用格茨的分油滴法进行的微穿刺实验表明，向近端肾小管腔内注射多巴胺（10⁻⁴ 摩尔/升）后，跨上皮液体转运受到刺激。同时注射普萘洛尔（10⁻³ 摩尔/升）可消除这种效应，而普萘洛尔本身并不影响跨肾小管容积通量。得出的结论是，多巴胺通过刺激β-肾上腺素能受体，可能增加近端肾小管上皮细胞的重吸收能力，而与肾血流动力学的变化无关。
