Kevanishvili Z Sh, von Specht H, Chkhartishvili B V, Lagidze Z P, Trushina Z V
Neirofiziologiia. 1977;9(1):3-10.
Regular changes in latencies of slow auditory evoked potentials were found with age. In particular, peak-latencies of comparatively early deflections, i.e. P1, N1 and P2, progressively diminished. The shortening of latencies was 50-60 ms for the age between 3-7, 8-13, and 25-35 msec further on. The latencies of the later waves, namely P3, N3 and P4, increased by 35-65 ms for the age between 3-7 and 8-13. After these ages, the latency of deflection P3 did not change, while deflections N3 and P4 disappeared. Of all the evoked potential components deflection N2 was the most stable, its latency negligibly shortened with age. In children aged 3-7 two complexes of waves (P1N1P2 and P2N2P3) often overlapped, forming a broad nondifferentiated deflection. The division of the latter was completed at the age of about 8. Long-term developmental changes in wave-shape and parameters of the slow evoked potentials are considered as supporting their mainly nonspecific (extralemniscal) orgin. Basing on correlation revealed between the late evoked potential components and EEG synchronization level, a hypothesis is advanced according to which these components are generated with participation of the nonspecific synchronizing system.
研究发现，慢听觉诱发电位的潜伏期会随着年龄发生规律性变化。具体而言，相对较早波峰的潜伏期，即P1、N1和P2，会逐渐缩短。在3至7岁之间，潜伏期缩短50至60毫秒，此后在8至13岁以及25至35岁之间，潜伏期进一步缩短8至13毫秒。较晚波峰，即P3、N3和P4的潜伏期，在3至7岁和8至13岁之间增加35至65毫秒。在这些年龄之后，P3波峰的潜伏期不再变化，而N3和P4波峰消失。在所有诱发电位成分中，N2波峰最稳定，其潜伏期随年龄增长略有缩短。在3至7岁的儿童中，两组波（P1N1P2和P2N2P3）经常重叠，形成一个宽大的未分化波峰。这种分化在大约8岁时完成。慢诱发电位波形和参数的长期发育变化被认为支持其主要是非特异性（丘脑外）起源。基于晚期诱发电位成分与脑电图同步水平之间的相关性，提出了一种假说，即这些成分是在非特异性同步系统的参与下产生的。
