Zheng H J, Tao Z H, Cheng W F, Wang S H, Cheng S Z, Ye Y M, Luo L F, Chen X R, Gan G B, Piessens W F
Guizhou Provincial Institute of Parasitic Diseases, Guiyang, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1993;11(1):33-7.
We compared the effect of a single dose of ivermectin (100 micrograms/kg) with that of a standard course of diethylcarbamazine (DEC) (6 mg/kg) on several parameters of the host's antifilarial immune response in 60 patients with bancroftian filariasis enrolled in a double-blind drug trial. All participants had measurable serum levels of antifilarial antibodies and parasite antigens. Drug-induced clearance of microfilaremia was associated with a temporary increase in HC11 antigenemia and a decrease in serum levels of antibodies to soluble filarial antigens. Antigenemia progressively declined in patients who remained a microfilaremic after treatment, but declined and then rose in persons with recurrent microfilaremia. Treatment triggered a sustained increase in serum levels of IL-1, IL-6, TNF alpha and IFN gamma in all patients. Although Ivermectin and DEC are believed to exert their antiparasite activity via different mechanisms, the same pattern of serological changes was observed in patients treated with either drug.
在一项双盲药物试验中，我们比较了单剂量伊维菌素（100微克/千克）与标准疗程乙胺嗪（DEC）（6毫克/千克）对60例班氏丝虫病患者宿主抗丝虫免疫反应若干参数的影响。所有参与者的血清中均可检测到抗丝虫抗体和寄生虫抗原。药物诱导的微丝蚴血症清除与HC11抗原血症的暂时升高以及可溶性丝虫抗原抗体血清水平的降低有关。治疗后仍有微丝蚴血症的患者，抗原血症逐渐下降，但微丝蚴血症复发的患者，抗原血症先下降后上升。治疗引发所有患者血清中IL-1、IL-6、TNF-α和IFN-γ水平持续升高。尽管伊维菌素和乙胺嗪被认为通过不同机制发挥抗寄生虫活性，但在接受这两种药物治疗的患者中观察到相同的血清学变化模式。
