Milburn C M, Prince D A
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94305.
Brain Res Dev Brain Res. 1993 Jul 16;74(1):133-7. doi: 10.1016/0165-3806(93)90093-p.
Muscarinic depression of field potential excitatory postsynaptic potentials (fEPSPs) in striatum radiatum of area CA1 was compared in hippocampal slices from rats of different ages. Bath application of 4 microM muscarine reversibly depressed the fEPSP slope by 68.4% in slices from adult animals (P43-P60), but caused only a 32.2% depression in slices from P5-P7 animals. The magnitude of the depression increased with age during the first postnatal month. Reduced sensitivity of excitatory synaptic transmission to cholinergic depression during postnatal development could be one factor contributing to the hyperexcitability of immature hippocampus.
比较了不同年龄大鼠海马切片中，毒蕈碱对CA1区辐射层纹状体场电位兴奋性突触后电位（fEPSP）的抑制作用。在成年动物（出生后43 - 60天）的切片中，浴槽应用4 microM毒蕈碱可使fEPSP斜率可逆性降低68.4%（P < 0.01），但在出生后5 - 7天动物的切片中，仅引起32.2%的抑制。在出生后的第一个月内，抑制程度随年龄增加。出生后发育过程中兴奋性突触传递对胆碱能抑制的敏感性降低，可能是导致未成熟海马兴奋性过高的一个因素。
