通过原位杂交将骨骼肌L型电压依赖性钙通道基因（CACNLG）的γ亚基定位于人类染色体带17q24，并鉴定该基因座处的一个多态性重复DNA序列。
Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus.
作者信息
Iles D E, Segers B, Weghuis D O, Suikerbuijk R, Wieringa B
机构信息
Department of Cell Biology and Histology, Faculty of Medical Sciences, Catholic University of Nijmegen, The Netherlands.
出版信息
Cytogenet Cell Genet. 1993;64(3-4):227-30. doi: 10.1159/000133583.
PMID:8404045
Abstract
The skeletal muscle dihydropyridine receptor consists of five subunits and fulfils an essential role in excitation-contraction coupling. A genomic clone for the human gamma subunit was used to map the gene (CACNLG) to chromosome band 17q24 by in situ hybridization. Contained within the gene is a 416-bp polymorphic repetitive DNA element that is potentially useful as a genetic marker.
摘要
骨骼肌二氢吡啶受体由五个亚基组成，在兴奋-收缩偶联中起重要作用。利用人类γ亚基的基因组克隆，通过原位杂交将该基因（CACNLG）定位于染色体17q24带。该基因包含一个416bp的多态性重复DNA元件，它有可能用作遗传标记。
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