Rolny P, Arlebäck A
Department of Medicine, Ostra Hospital, University of Göteborg, Sweden.
Endoscopy. 1993 Aug;25(6):381-3. doi: 10.1055/s-2007-1010344.
Midazolam is a more recent benzodiazepine used for sedation during endoscopic procedures, including sphincter of Oddi (SO) manometry. However, the effect of this drug on the human SO has so far not been studied. In this paper we explored the effect of midazolam on human SO motility by means of endoscopic manometry. Twelve patients with suspected SO dysfunction were investigated. We found that in patients with normal manometry findings, midazolam had no effect on the sphincter motility. In contrast, in all patients with elevated SO pressure (SOP), as well as in one of the three patients with borderline SO tone, midazolam (2.5 mg i.v.) produced a relaxatory effect. Due to this effect the final readings were affected in three out of five patients, i.e. the abnormally elevated SOP decreased to a borderline level in two and in the remaining patient the borderline level in two and in the remaining patient the borderline SOP decreased to normal. In one other patient with a markedly elevated SOP the additional injection of 2.5 mg of midazolam caused a further decrease in SOP to a borderline level. We conclude that midazolam, due to its relaxatory effect on SO, appears to be a less suitable sedative for SO manometry.
咪达唑仑是一种较新的苯二氮䓬类药物，用于内镜检查过程中的镇静，包括Oddi括约肌（SO）测压。然而，该药物对人体SO的影响迄今为止尚未得到研究。在本文中，我们通过内镜测压法探讨了咪达唑仑对人体SO运动的影响。对12例疑似SO功能障碍的患者进行了研究。我们发现，在测压结果正常的患者中，咪达唑仑对括约肌运动没有影响。相反，在所有SO压力（SOP）升高的患者以及3例SO张力临界患者中的1例中，咪达唑仑（静脉注射2.5mg）产生了松弛作用。由于这种作用，5例患者中有3例的最终读数受到影响，即2例异常升高的SOP降至临界水平，其余1例患者的临界SOP降至正常。在另1例SOP明显升高的患者中，额外注射2.5mg咪达唑仑导致SOP进一步降至临界水平。我们得出结论，由于咪达唑仑对SO有松弛作用，它似乎不太适合用于SO测压的镇静。
