Heijmans H J, Mehta D, Kleibeuker J H, Sluiter W J, Hoekstra H J
Department of Surgical Oncology, Groningen University Hospital, The Netherlands.
Eur Surg Res. 1993;25(5):321-8. doi: 10.1159/000129296.
A canine model is described to study the tolerance of the pancreas to intra-operative radiotherapy (IORT). The canine pancreas is a horseshoe-shaped organ. To create a homogeneous delivery of IORT to the whole pancreas surgical manipulation is necessary which may induce pancreatitis. A resection of the left and right lobes of the pancreas facilitates the delivery of IORT, reduces the risk of pancreatitis and will demonstrate, eventually, minimal functional changes in the exocrine and endocrine pancreas at an earlier stage. Sixteen beagles were used. Investigations before and after the reduction procedure were intravenous glucose tolerance tests, serum insulin levels, faecal fat excretion, blood chemistry tests and body weight. Eight weeks after the pancreas reduction 15 dogs underwent an IORT procedure in which 25, 30 or 35 Gy IORT was delivered to the pancreatic remnant. We conclude that the pancreas reduction technique used to study the effects of IORT to the canine pancreas is feasible without mortality or morbidity. Endocrine and exocrine pancreatic function remained normal with a minimal follow-up of 3 months.
描述了一种犬类模型，用于研究胰腺对术中放疗（IORT）的耐受性。犬胰腺是一个马蹄形器官。为了使IORT均匀地作用于整个胰腺，需要进行手术操作，而这可能会诱发胰腺炎。切除胰腺的左右叶有助于IORT的实施，降低胰腺炎的风险，并最终在早期显示出胰腺外分泌和内分泌功能的最小变化。使用了16只比格犬。在缩小手术前后进行的检查包括静脉葡萄糖耐量试验、血清胰岛素水平、粪便脂肪排泄、血液化学检查和体重。胰腺缩小术后8周，15只狗接受了IORT手术，向胰腺残余部分给予25、30或35 Gy的IORT。我们得出结论，用于研究IORT对犬胰腺影响的胰腺缩小技术是可行的，没有死亡率或发病率。在至少3个月的最短随访期内，胰腺内分泌和外分泌功能保持正常。
