葡萄球菌肠毒素B上调扁桃体B细胞上白细胞介素-2受体β链的表达。
Staphylococcal enterotoxin B up-regulates interleukin-2 receptor beta chain expression on tonsillar B cells.
作者信息
Franz A, Bryant A, Farrant J
机构信息
Immunodeficiency Diseases Research Group, Clinical Research Centre, Harrow, GB.
出版信息
Eur J Immunol. 1993 Oct;23(10):2696-9. doi: 10.1002/eji.1830231047.
The superantigen staphylococcal enterotoxin B (SEB) selectively up-regulates the interleukin-2 receptor (IL-2R) beta chain (p70) without up-regulating the IL-2R alpha chain (CD25) on a human tonsillar B cell population depleted of T cells. This action of SEB, probably mediated by binding to major histocompatibility complex class II, renders B cells sensitive to T cell-derived IL-2 and is sufficient for induction of vigorous DNA synthesis with low concentrations of IL-2. This explains one of the mechanisms by which bacterial superantigens activate large numbers of B cells and may reflect a similar mechanism operative in cognate helper T cell/B cell interactions.
超抗原葡萄球菌肠毒素B（SEB）在去除T细胞的人扁桃体B细胞群体中，选择性地上调白细胞介素2受体（IL-2R）β链（p70），而不上调IL-2Rα链（CD25）。SEB的这一作用可能是通过与主要组织相容性复合体II类结合介导的，使B细胞对T细胞衍生的IL-2敏感，并且在低浓度IL-2存在时足以诱导强烈的DNA合成。这解释了细菌超抗原激活大量B细胞的机制之一，并且可能反映了在同源辅助性T细胞/B细胞相互作用中起作用的类似机制。
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