Acuña-Castroviejo D, Fernández B, Castillo J L, del Aguila C M
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Spain.
Experientia. 1993 Sep 15;49(9):797-801. doi: 10.1007/BF01923552.
The aim of this study was to compare the effects of pineal indole treatments on LH and FSH release in pinealectomized and suprachiasmatic lesioned and ovariectomized rats rendered hyperprolactinemic by acute sulpiride treatment. Pinealectomy or suprachiasmatic nuclei lesions in female rats both decreased plasma LH and FHS at 10, but not at 20 d after surgery, whereas the daily afternoon administration of melatonin effectively restored levels of both gonadotropins to control values. In ovariectomized rats, pinealectomy or suprachiasmatic nuclei lesions were ineffective in counteracting the high plasma levels of LH and FSH. However, sulpiride treatment in both pinealectomized and suprachiasmatic nuclei lesioned and castrated female rats significantly decreased the levels of LH and FSH, an effect which was counteracted by daily afternoon melatonin administration. Other pineal indoles tested, i.e., 5-hydroxy- and 5-methoxytryptophol, were ineffective in regulating gonadotropin levels. The results suggest that the pineal gland, through its hormone melatonin, can modulate gonadotropin secretion by acting on a dopamine mechanism independent of hypothalamic suprachiasmatic areas.
本研究的目的是比较松果体吲哚处理对松果体切除、视交叉上核损伤以及通过急性舒必利处理导致高催乳素血症的去卵巢大鼠促黄体生成素（LH）和促卵泡生成素（FSH）释放的影响。雌性大鼠的松果体切除或视交叉上核损伤在术后10天均降低了血浆LH和FHS水平，但在术后20天未出现这种情况，而每日下午给予褪黑素可有效将两种促性腺激素水平恢复至对照值。在去卵巢大鼠中，松果体切除或视交叉上核损伤在抵消LH和FSH的高血浆水平方面无效。然而，在松果体切除、视交叉上核损伤以及去势的雌性大鼠中，舒必利处理均显著降低了LH和FSH水平，每日下午给予褪黑素可抵消这一作用。所测试的其他松果体吲哚，即5-羟基色醇和5-甲氧基色醇，在调节促性腺激素水平方面无效。结果表明，松果体通过其激素褪黑素，可通过作用于独立于下丘脑视交叉上区域的多巴胺机制来调节促性腺激素分泌。
