Esquifino A I, Ramos J A, Tresguerres J A
J Endocrinol. 1984 Feb;100(2):141-8. doi: 10.1677/joe.0.1000141.
Nine-month-old female rats bearing an ectopic pituitary gland (from a litter-mate) under the right kidney capsule since day 30 of life and their sham-operated controls, were treated with a dopamine agonist (lysuride) or antagonist (metoclopramide). Plasma prolactin and LH levels were measured by double-antibody radioimmunoassays. Vaginal smears were taken before and during the treatment periods. Eight months after the operation, a significant (P less than 0.01) increase in basal prolactin levels together with a significant (P less than 0.05) reduction in LH values and permanent dioestrus occurred in the grafted animals when compared with controls. Lysuride treatment resulted in a marked reduction in plasma prolactin levels both in control and grafted rats over the whole 12 days of treatment, together with a partial restoration of plasma LH levels on day 1. From day 7 onwards a depression in LH values was again observed. Oestrous cycles were partially restored at the beginning of the treatment, but after 7 days dioestrus returned. Metoclopramide administration induced a significant (P less than 0.001) increase in basal prolactin levels in both grafted and control rats. Basal plasma LH values were unaffected in controls when compared with vehicle-treated animals. An increase could be seen in hyperprolactinaemic rats after 7 or 12 days of treatment however. The LH response to the administration of LH releasing hormone (LHRH) was greater in the experimental and control metoclopramide-treated rats when compared with vehicle-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
自出生第30天起在右肾包膜下移植了异位垂体（取自同窝仔鼠）的9月龄雌性大鼠及其假手术对照组，接受了多巴胺激动剂（利舒脲）或拮抗剂（甲氧氯普胺）治疗。采用双抗体放射免疫分析法测定血浆催乳素和促黄体生成素水平。在治疗前后采集阴道涂片。术后8个月，与对照组相比，移植大鼠的基础催乳素水平显著升高（P<0.01），促黄体生成素值显著降低（P<0.05），并出现永久性静止期。在整个12天的治疗过程中，利舒脲治疗使对照组和移植大鼠的血浆催乳素水平显著降低，同时在第1天血浆促黄体生成素水平部分恢复。从第7天起，促黄体生成素值再次下降。在治疗开始时，发情周期部分恢复，但7天后又回到静止期。给予甲氧氯普胺使移植大鼠和对照大鼠的基础催乳素水平显著升高（P<0.001）。与给予赋形剂的动物相比，对照组的基础血浆促黄体生成素值未受影响。然而，在高催乳素血症大鼠中，治疗7天或12天后促黄体生成素水平有所升高。与给予赋形剂的大鼠相比，实验性和对照性甲氧氯普胺治疗大鼠对促黄体生成素释放激素（LHRH）给药的促黄体生成素反应更大。（摘要截短至250字）
