Pallet V, Coustaut M, Naulet F, Higueret D, Garcin H, Higueret P
Laboratoire de Nutrition, ISTAB, Université Bordeaux I, Talence, France.
FEBS Lett. 1993 Sep 27;331(1-2):119-22. doi: 10.1016/0014-5793(93)80309-i.
Chronic alcoholism induces perturbations of storage and metabolization of retinol and related compounds. After 6 months of ethanol consumption we have observed in mouse liver an increased expression of Tri-iodothyronine receptors (TR) while the expression of retinoic acid (RA) receptors (RAR) was unaffected. After 10 months of alcoholization the TR expression was strongly increased and the RAR expression was also increased. At this time the activity of aldehyde dehydrogenase and that of alcohol dehydrogenase, two enzymes involved in biosynthesis of RA from retinol, were similar in the liver of alcoholized and pair-fed mice. Thus it can be hypothesized that (i) the change of RAR expression was, at least in part, the result of a change of TR expression (result in agreement with previous data), (ii) the increased expression of RAR could induce apoptosis and subsequently liver necrosis.
慢性酒精中毒会引起视黄醇及相关化合物储存和代谢的紊乱。在小鼠摄入乙醇6个月后，我们观察到其肝脏中三碘甲状腺原氨酸受体（TR）的表达增加，而视黄酸（RA）受体（RAR）的表达未受影响。酒精化10个月后，TR表达大幅增加，RAR表达也增加。此时，在酒精化小鼠和配对喂养小鼠的肝脏中，参与从视黄醇生物合成RA的两种酶——醛脱氢酶和乙醇脱氢酶的活性相似。因此可以推测：（i）RAR表达的变化至少部分是TR表达变化的结果（这一结果与先前数据一致）；（ii）RAR表达增加可能诱导细胞凋亡并随后导致肝坏死。
