Malignant fibrous histiocytoma arising in a previous site of fracture and osteomyelitis.

Malignant fibrous histiocytomas (MFH) are known to arise in benign pre-existing conditions. We present here a case where MFH occurred more than 40 years after a fracture and infection. The diagnosis was established only after repeated clinical and histopathologic examinations. DNA flow cytometric and chromosomal analyses were also done.