Church M W, Kaltenbach J A
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan.
Ear Hear. 1993 Aug;14(4):249-57. doi: 10.1097/00003446-199308000-00004.
Young adult hamsters were evaluated for normal variations in the auditory brain stem response (ABR) and for the effects of hearing loss. Normal variations in the ABR's latencies and amplitudes were defined for both click and tone burst stimuli over a broad range of intensities. As stimulus intensity decreased from 100 to 15 dB pe SPL, the ABR latencies were prolonged, the P4-P1 interpeak latencies varied in a complex manner, and amplitudes decreased. As tone burst frequency decreased from 8000 to 4000 and then to 2000 Hz, ABR latencies were prolonged, amplitudes decreased, and thresholds increased. The P4-P1 interpeak latencies were also influenced by tone burst frequency, with the longest interpeak latencies occurring in response to the 2000 Hz tone bursts. Data from two hamsters with hearing loss were compared to the normal data to illustrate how the ABR can be used to describe experimentally induced hearing impairment. Hearing impairment was induced by rearing animals in ambient noise. These animals showed elevated ABR thresholds at all three frequencies and upward displacements in the ABR's latency-intensity profiles.
对年轻成年仓鼠的听觉脑干反应（ABR）的正常变化以及听力损失的影响进行了评估。针对广泛强度范围内的短声和短纯音刺激，确定了ABR潜伏期和振幅的正常变化。当刺激强度从100 dB pe SPL降至15 dB时，ABR潜伏期延长，P4 - P1峰间潜伏期以复杂的方式变化，振幅减小。当短纯音频率从8000 Hz降至4000 Hz，然后再降至2000 Hz时，ABR潜伏期延长，振幅减小，阈值增加。P4 - P1峰间潜伏期也受短纯音频率影响，对2000 Hz短纯音反应时峰间潜伏期最长。将两只听力损失仓鼠的数据与正常数据进行比较，以说明如何使用ABR来描述实验性诱导的听力损伤。通过在环境噪声中饲养动物诱导听力损伤。这些动物在所有三个频率下ABR阈值均升高，且ABR潜伏期 - 强度曲线向上移位。
