Loftus N J, Laird W J, Steel G T, Wilks M F, Woollen B H
Zeneca Central Toxicology Laboratory, Investigative Toxicology Section, Macclesfield, Cheshire, UK.
Food Chem Toxicol. 1993 Sep;31(9):609-14. doi: 10.1016/0278-6915(93)90042-w.
The metabolism and pharmacokinetics of [2H10]di-2-(ethylhexyl) adipate (DEHA) labelled on the ethyl side-chains was determined in six male volunteers. The dose administered was 46 mg [2H10]DEHA given orally. No parent molecule was found in plasma; however, the metabolite [2H5]2-ethylhexanoic acid (EHA) was detected (mean rate of formation: 1.63 +/- 1.19/hr; mean rate of elimination: 0.42 +/- 0.1/hr). Further oxidative metabolism products were detected in urine; the dominant metabolite identified was EHA present as a conjugate and accounted for an average of 8.6% of the administered dose. [2H5]2-Ethyl-5-hydroxyhexanoic acid, [2H5]2-ethylhexanedioic acid, [2H5]2-ethyl-5-keto-hexanoic acid and [2H5]2-ethylhexanol together accounted for a further 3.5% of the dose. The fate of the remainder was not determined.
在六名男性志愿者中测定了在乙基侧链上标记的[2H10]己二酸二（2-乙基己基）酯（DEHA）的代谢和药代动力学。口服给予的剂量为46毫克[2H10]DEHA。血浆中未发现母体分子；然而，检测到代谢物[2H5]2-乙基己酸（EHA）（平均生成速率：1.63±1.19/小时；平均消除速率：0.42±0.1/小时）。在尿液中检测到进一步的氧化代谢产物；鉴定出的主要代谢物是作为缀合物存在的EHA，平均占给药剂量的8.6%。[2H5]2-乙基-5-羟基己酸、[2H5]2-乙基己二酸、[2H5]2-乙基-5-酮基己酸和[2H5]2-乙基己醇合起来又占剂量的3.5%。其余部分的去向未确定。
