Kobrehel G, Lazarevski G, Kelnerić Z, Dokić S
PLIVA, Research Institute, Prilaz baruna Filipovića, Croatia.
J Antibiot (Tokyo). 1993 Aug;46(8):1239-45. doi: 10.7164/antibiotics.46.1239.
The novel 9a,11-cyclic carbamates (13-15) of 9-deoxo-9a-aza-9a-homoerythromycin A (4) have been prepared and characterized by 1H-1H and 1H-13C 2D NMR spectroscopy. When compared to azithromycin (1) or its 6-O-methyl derivative (2), the new bicyclic 15-membered azalides exhibited substantially decreased antibacterial activities in vitro.
9-脱氧-9a-氮杂-9a-高红霉素A（4）的新型9a,11-环氨基甲酸酯（13 - 15）已被制备，并通过1H-1H和1H-13C二维核磁共振光谱进行了表征。与阿奇霉素（1）或其6-O-甲基衍生物（2）相比，新型双环15元氮杂内酯在体外表现出显著降低的抗菌活性。
