Kim T K, Roeder R G
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
J Biol Chem. 1993 Oct 5;268(28):20866-9.
Among eukaryotic transcriptional activators, those with acidic activation domains have been shown to stimulate transcription in organisms ranging from yeast to human. In vivo and in vitro assays have been employed to demonstrate transcriptional enhancement in yeast by the proline-rich activation domain of human CTF1. This result suggests that proline-rich activation domains may, like typical acidic activation domains, functional universally.
在真核转录激活因子中，具有酸性激活结构域的那些已被证明能在从酵母到人类的各种生物体中刺激转录。体内和体外试验已被用于证明人CTF1富含脯氨酸的激活结构域在酵母中能增强转录。这一结果表明，富含脯氨酸的激活结构域可能像典型的酸性激活结构域一样具有普遍功能。
