Muszynski C A, Robertson C S, Goodman J C, Henley C M
Department of Otorhinolaryngology, Baylor College of Medicine 77030.
J Cereb Blood Flow Metab. 1993 Nov;13(6):1033-7. doi: 10.1038/jcbfm.1993.131.
Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is induced in ischemic tissue and may mediate vasogenic edema and delayed neuronal death. We determined the effects of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC, on infarct size and ODC activity in a rat model of transient focal ischemia. DFMO blocked the ischemia-induced increase in ODC and significantly reduced infarct volumes by 57-45%, depending upon the treatment regimen. These studies suggest that polyamine metabolism plays a role in the development of cerebral infarction after focal ischemia and that DFMO may be useful in limiting injury after a stroke.
鸟氨酸脱羧酶（ODC）是多胺生物合成中的关键酶，在缺血组织中被诱导表达，可能介导血管源性水肿和迟发性神经元死亡。我们在大鼠短暂性局灶性缺血模型中，确定了ODC特异性抑制剂α-二氟甲基鸟氨酸（DFMO）对梗死面积和ODC活性的影响。DFMO可阻断缺血诱导的ODC增加，并根据治疗方案使梗死体积显著减少57%至45%。这些研究表明，多胺代谢在局灶性缺血后脑梗死的发展中起作用，且DFMO可能有助于限制中风后的损伤。
