Sisson J C, Ackermann R J, Meyer M A, Wahl R L
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028.
J Clin Endocrinol Metab. 1993 Oct;77(4):1090-4. doi: 10.1210/jcem.77.4.8408458.
A patient developed a pulmonary metastasis from papillary thyroid carcinoma. This tumor concentrated relatively little 131I, but sufficient 18F-fluoro-2-deoxy-D-glucose (FDG) to be quantified and imaged by positron emission tomography. The uptake of FDG was lower on positron emission tomographic images after T4 therapy and when the serum TSH concentration was reduced to the low normal range. It may be possible to use decreases in FDG uptake by thyroid cancers, which represent declines in metabolism by the tumors, to indicate the optimum doses of T4 treatment for patients with these neoplasms. In addition, the ratio of tumor to background radioactivity was higher for FDG than for the flow agent 201Tl, so that studies with FDG may be a useful scintigraphic method for locating thyroid cancers when radioiodine imaging is unsatisfactory.
一名患者发生了甲状腺乳头状癌肺转移。该肿瘤摄取的¹³¹I相对较少，但摄取了足够量的¹⁸F - 氟 - 2 - 脱氧 - D - 葡萄糖（FDG），可通过正电子发射断层扫描进行定量和成像。在T4治疗后以及血清促甲状腺激素（TSH）浓度降至低正常范围时，正电子发射断层扫描图像上FDG的摄取量较低。利用甲状腺癌FDG摄取量的降低（这代表肿瘤代谢的下降）来指示这些肿瘤患者的最佳T4治疗剂量或许是可行的。此外，FDG的肿瘤与本底放射性比值高于流注剂²⁰¹Tl，因此当放射性碘成像不满意时，FDG研究可能是一种用于定位甲状腺癌的有用闪烁显像方法。
