Kohn D, Kohn S
Department of Geriatrics, Lady Davis Carmel Hospital, Haifa, Israel.
J Dermatol. 1993 Jul;20(7):413-7. doi: 10.1111/j.1346-8138.1993.tb01309.x.
An ultrastructural and morphometric study compared Langerhans' cells in sacral epidermis, 8-10 cm from the lesion of patients (mean age 70) with decubital ulcers, with those in the patients' own normal epidermis from the upper leg and with those in the epidermis from the upper leg of normal age-matched volunteers. The Langerhans' cell section area was significantly lower in patients' control leg epidermis (25.86 +/- 2.29 microns2) than in that from normal controls (35.74 +/- 3.76 microns2) or that from patients' sacral epidermis near the lesion (41.26 +/- 3.45). The number of Langerhans' cell granules was higher in control leg epidermis of patients (10.22 +/- 1.26) and was significantly higher in lesioned sacral epidermis (12.94 +/- 1.90) than in normal controls (6.97 +/- 1.47). In Langerhans' cells in patients' epidermis, formative stages of Langerhans' cell granules were observed. The findings may indicate that Langerhans' cells in patients' epidermis are in an active state.
一项超微结构和形态计量学研究比较了患有褥疮溃疡患者（平均年龄70岁）距病变8 - 10厘米处骶部表皮中的朗格汉斯细胞，与患者自身大腿上部正常表皮中的朗格汉斯细胞，以及年龄匹配的正常志愿者大腿上部表皮中的朗格汉斯细胞。患者对照腿部表皮中朗格汉斯细胞的切片面积（25.86±2.29平方微米）显著低于正常对照组（35.74±3.76平方微米）或患者病变附近骶部表皮中的切片面积（41.26±3.45）。患者对照腿部表皮中朗格汉斯细胞颗粒的数量（10.22±1.26）较高，且病变骶部表皮中的数量（12.94±1.90）显著高于正常对照组（6.97±1.47）。在患者表皮的朗格汉斯细胞中，观察到了朗格汉斯细胞颗粒的形成阶段。这些发现可能表明患者表皮中的朗格汉斯细胞处于活跃状态。
