O'Carroll R E, Moffoot A P, Van Beck M, Dougall N, Murray C, Ebmeier K P, Goodwin G M
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, UK.
J Affect Disord. 1993 Jul;28(3):203-10. doi: 10.1016/0165-0327(93)90106-t.
Ten patients suffering from DSM-III-R simple phobia were studied under two conditions: (a) while listening to a 4 min relaxation tape, and (b) while listening to a 4 min audio tape describing exposure to the phobic stimulus. During each condition, subjects were injected with 99mTc-Exametazime, a marker of regional cerebral blood flow. Subjective and psychophysiological measures indicated a marked effect of the anxiety induction procedure. Ratio analysis of the SPET data revealed reductions in tracer uptake largely confined to posterior cerebral regions bilaterally. Analysis of brain regions of interest normalised to the whole brain slice showed reductions confined to right temporal/occipital regions. In general there was no clear association between subjective and physiological variables and changes in regional uptake of tracer as a consequence of the anxiety induction procedure. The changes in tracer uptake were dissimilar to those previously reported for other cognitive activation paradigms, providing some reassurance that those functional brain changes were not artefacts of non-specific changes in state anxiety. These posterior brain changes may reflect alterations in activation of the GABA/benzodiazepine complex.
对10名患有DSM-III-R单纯恐惧症的患者在两种条件下进行了研究：（a）听4分钟的放松磁带时；（b）听4分钟描述暴露于恐惧刺激的录音带时。在每种条件下，给受试者注射99mTc-依沙美肟，这是一种局部脑血流标记物。主观和心理生理测量表明焦虑诱导程序有显著效果。单光子发射计算机断层扫描（SPET）数据的比率分析显示，示踪剂摄取减少主要局限于双侧大脑后部区域。对归一化到整个脑切片的感兴趣脑区分析显示，减少局限于右侧颞叶/枕叶区域。总体而言，主观和生理变量与焦虑诱导程序导致的示踪剂局部摄取变化之间没有明显关联。示踪剂摄取的变化与先前报道的其他认知激活范式的变化不同，这让人放心，那些功能性脑变化不是状态焦虑非特异性变化的伪像。这些大脑后部的变化可能反映了γ-氨基丁酸/苯二氮䓬复合物激活的改变。
