Giri O P
Department of Medicine, Darbhanga Medical College and Hospital, Laherisarai.
J Indian Med Assoc. 1993 Apr;91(4):91-3.
Twenty-seven adult patients of kala-azar unresponsive to sodium stibogluconate (SSG) were given amphotericin B in the dose schedule of 0.50 mg/kg body weight on alternate days for a total of 21 to 31 infusions, depending upon clinical and parasitological response. A 100% cure rate was achieved at the end of the therapy and no relapse was encountered during 12 months follow-up. Only mild adverse reactions were noted on the day of infusion during therapy. Amphotericin B was found to be an acceptable alternative drug for treatment of such cases.
27例对葡萄糖酸锑钠（SSG）无反应的黑热病成年患者，按照0.50mg/kg体重的剂量隔日给予两性霉素B，根据临床和寄生虫学反应，总共输注21至31次。治疗结束时治愈率达100%，在12个月的随访期间未出现复发。治疗期间仅在输注当天出现轻微不良反应。两性霉素B被发现是治疗此类病例的一种可接受的替代药物。
