Torgersen S, Gilhuus-Moe O T, Gjerdet N R
Department of Maxillofacial Surgery, Haukeland Hospital, Bergen, Norway.
Int J Oral Maxillofac Surg. 1993 Aug;22(4):246-50. doi: 10.1016/s0901-5027(05)80647-2.
Fifteen patients undergoing internal fixation for mandibular fractures were examined for delayed type hypersensitivity (DTH) reaction to nickel before and after implantation of stainless steel miniplates. A lymphocyte transformation test (LTT) was used to measure the immune response before implantation and at removal of plates and screws. The clinical complications during fracture healing were also recorded. The results show that the in vitro LTT may be useful in nickel hypersensitivity testing. A significant increase in lymphocyte transformation was found as a response to nickel stimulation (0.5 microgram Ni/ml) at removal of the implants. We conclude that, despite an increase in LTT after stainless steel implantation, no adverse clinical complications related to DTH could be recorded after short-time observation.
对15例接受下颌骨骨折内固定治疗的患者，在植入不锈钢微型钢板前后检测其对镍的迟发型超敏反应（DTH）。采用淋巴细胞转化试验（LTT）在植入前及取出钢板和螺钉时测量免疫反应。同时记录骨折愈合过程中的临床并发症。结果表明，体外LTT可能有助于镍超敏反应检测。在取出植入物时，发现对镍刺激（0.5微克镍/毫升）的淋巴细胞转化有显著增加。我们得出结论，尽管不锈钢植入后LTT有所增加，但短期观察后未发现与DTH相关的不良临床并发症。
