D'Erasmo E, Acca M, Celi F S, Medici F, Palmerini T, Pisani D
II Clinica Medica, University of Rome La Sapienza, Italy.
J Med. 1993;24(2-3):185-91.
Plasma fibrinogen levels and platelet counts were evaluated in 30 patients with acute ischemic cerebral infarction (CI) three and nine days after the onset of symptoms. Hyperfibrinogenemia (379.4 +/- 80.3 vs 327.3 +/- 48.3 mg/dL of controls, p < 0.005), a reduction of platelet count (207.133 +/- 48.388 vs 288.375 +/- 61.373 x 10(9)/L of controls, p < 0.001), and an inverse correlation (r = -0.41, p < 0.05) between the two parameters were observed on day three. On day nine, platelet counts normalized while plasma fibrinogen levels slightly increased; the inverse correlation no longer occurred. The results suggest that in the earliest phase of stroke plasma fibrinogen levels may condition the extent of platelet accumulation or consumption in the ischemic area. This confirms in vivo that the platelet aggregation process is strictly dependent on fibrinogen concentration.
对30例急性缺血性脑梗死（CI）患者在症状发作后3天和9天评估血浆纤维蛋白原水平和血小板计数。在第3天观察到高纤维蛋白原血症（379.4±80.3 vs对照组327.3±48.3mg/dL，p<0.005）、血小板计数降低（207.133±48.388 vs对照组288.375±61.373×10⁹/L，p<0.001）以及这两个参数之间的负相关（r=-0.41，p<0.05）。在第9天，血小板计数恢复正常，而血浆纤维蛋白原水平略有升高；负相关不再出现。结果表明，在中风的最早阶段，血浆纤维蛋白原水平可能影响缺血区域血小板聚集或消耗的程度。这在体内证实血小板聚集过程严格依赖于纤维蛋白原浓度。
