Yassini P R, Sauter K, Schochet S S, Kaufman H H, Bloomfield S M
Department of Neurosurgery, West Virginia University School of Medicine, Morgantown.
J Neurosurg. 1993 Nov;79(5):774-8. doi: 10.3171/jns.1993.79.5.0774.
Hypertrophic nerve lesions displaying onion-bulb cellular formations are quite rare in the absence of a generalized hypertrophic neuropathy. The isolated peripheral nerve lesion has been termed "localized hypertrophic mononeuropathy" (LHN), and fewer than 30 cases of this condition have been reported. Very little is known regarding the etiology and the natural course of this rare disorder. A unique case of LHN afflicting spinal roots in association with a sacral meningocele is reported with a brief review of the relevant literature. The unique features of this case not only reveal a variable clinical presentation of the disease but also support the theory that LHN may be a localized reaction to nerve trauma or entrapment.
在没有全身性肥厚性神经病变的情况下，出现洋葱球样细胞结构的肥厚性神经病变相当罕见。这种孤立的周围神经病变被称为“局限性肥厚性单神经病”（LHN），报道的此类病例不到30例。对于这种罕见疾病的病因和自然病程知之甚少。本文报告了一例与骶部脑脊膜膨出相关的累及脊神经根的LHN独特病例，并对相关文献进行简要综述。该病例的独特特征不仅揭示了该病多变的临床表现，还支持了LHN可能是对神经创伤或卡压的局部反应这一理论。
