妊娠和分娩期间牛胎盘子叶和母体胎盘的芳香化酶活性及雌激素浓度。

Aromatase activity and oestrogen concentrations in bovine cotyledons and caruncles during gestation and parturition.

作者信息

Tsumagari S, Kamata J, Takagi K, Tanemura K, Yosai A, Takeishi M

机构信息

Department of Veterinary Obstetrics and Gynecology, Nihon University, Kanagawa, Japan.

出版信息

J Reprod Fertil. 1993 Jul;98(2):631-6. doi: 10.1530/jrf.0.0980631.

DOI:10.1530/jrf.0.0980631

PMID:8410835

Abstract

Two peaks of aromatase activities were detected in bovine cotyledons, 2.76 +/- 0.96 pmol min-1 mg-1 protein at month five of gestation and 3.62 +/- 0.78 pmol min-1 mg-1 protein immediately after parturition, but aromatase activity in caruncles was very low throughout gestation. Oestrone concentrations in the cotyledons and caruncles were 0.93 +/- 0.50 and 1.51 +/- 0.69 ng mg-1 protein at month five of gestation, but 4.31 +/- 1.66 and 3.36 +/- 0.98 ng mg-1 protein immediately after parturition, indicating a biphasic pattern. Our findings suggest that oestrogen synthesis in the bovine placenta increased to a maximum at least twice during the period from gestation to parturition; at month five of gestation and at parturition the changes in aromatase activity may only be partially explained by changes in oestrogen production.

摘要

在牛的子叶中检测到两个芳香化酶活性高峰，妊娠第5个月时为2.76±0.96皮摩尔·分钟⁻¹·毫克⁻¹蛋白质，分娩后立即为3.62±0.78皮摩尔·分钟⁻¹·毫克⁻¹蛋白质，但在整个妊娠期，肉阜中的芳香化酶活性都非常低。妊娠第5个月时，子叶和肉阜中的雌酮浓度分别为0.93±0.50和1.51±0.69纳克·毫克⁻¹蛋白质，但分娩后立即分别为4.31±1.66和3.36±0.98纳克·毫克⁻¹蛋白质，呈现出双相模式。我们的研究结果表明，从妊娠到分娩期间，牛胎盘的雌激素合成至少在两个阶段增加到最大值；在妊娠第5个月和分娩时，芳香化酶活性的变化可能仅部分由雌激素产生的变化来解释。