Nehler M R, Moneta G L, Edwards J M, Yeager R A, Taylor L M, Porter J M
Division of Vascular Surgery, Oregon Health Sciences University, Portland.
J Vasc Surg. 1993 Oct;18(4):618-24; discussion 624-6.
Revascularization for chronic lower extremity ischemia (CLEI) in patients 80 or more years of age is controversial. High operative mortality, short remaining life span, and nonambulatory nursing home existence are cited as frequent outcomes in this patient group. Despite these considerations we have maintained an aggressive policy of lower extremity revascularization in functional and potentially functional patients 80 or more years of age with limb-threatening ischemia or claudication sufficient to threaten their independence.
The records of all patients 80 or more years of age who underwent lower extremity revascularization for CLEI from 1981 through 1991 were reviewed. Patients were evaluated for surgical indication, perioperative mortality, late survival, graft patency, and limb salvage. In addition, the patient's preoperative and postoperative independence determined by living situation (home versus nursing home) and ambulatory status were examined.
During the period reviewed 88 patients 80 or more years of age underwent 95 arterial reconstructions for CLEI; 95% for limb salvage and 5% for short-distance claudication. There were 81 (85%) infrainguinal bypasses and 14 (15%) extra-anatomic bypasses, 5 of which also included a simultaneously placed infrainguinal bypass. The perioperative mortality rate was 6%. Mean hospitalization was 18 days (range 6 to 62). The 1- and 3-year primary graft patency rates were 88% and 66%, limb salvage rates 94% and 91%, and patient survival rates 73% and 51%, respectively. One year after operation 88% of patients were ambulatory, 85% were living at home, and 80% were both living at home and ambulatory. At 3 years these results were 86%, 76%, and 71%, respectively. Of the patients living at home and ambulatory before operation, 100% and 84% of survivors were still living at home and ambulatory 1 and 3 years after operation. Of patients living at home who had late graft occlusions, 67% required amputation and subsequent nursing home placement.
Although survival in this group is predictably lower than that of age-matched control subjects, octogenarians have satisfactory 1- and 3-year graft patency, limb salvage, and functional results. Revascularization for CLEI in patients 80 or more years of age is appropriate and results in maintenance of independent living in a large majority.
80岁及以上患者慢性下肢缺血(CLEI)的血运重建存在争议。该患者群体常出现手术死亡率高、剩余寿命短以及非卧床养老院生活等情况。尽管有这些顾虑,但对于80岁及以上有肢体威胁性缺血或间歇性跛行足以威胁其独立性的功能健全和潜在功能健全的患者,我们一直保持积极的下肢血运重建策略。
回顾了1981年至1991年期间所有80岁及以上因CLEI接受下肢血运重建的患者记录。对患者进行手术指征、围手术期死亡率、远期生存率、移植物通畅率和肢体挽救情况评估。此外,还检查了患者术前和术后根据生活状况(家中与养老院)和活动状态确定的独立性。
在回顾期间,88例80岁及以上患者因CLEI接受了95次动脉重建;95%是为了挽救肢体,5%是为了治疗短距离间歇性跛行。有81例(85%)为腹股沟下旁路移植术,14例(15%)为解剖外旁路移植术,其中5例还同时进行了腹股沟下旁路移植术。围手术期死亡率为6%。平均住院时间为18天(范围6至62天)。1年和3年的原发性移植物通畅率分别为88%和66%,肢体挽救率分别为94%和91%,患者生存率分别为73%和51%。术后1年,88%的患者可活动,85%在家居住,80%既在家居住又可活动。3年时,这些结果分别为86%、76%和71%。术前在家居住且可活动的患者中,100%和84%的幸存者在术后1年和3年仍在家居住且可活动。在家居住且后期移植物闭塞的患者中,67%需要截肢并随后入住养老院。
尽管该组患者的生存率预计低于年龄匹配的对照组,但80多岁的患者1年和3年的移植物通畅率、肢体挽救率和功能结果令人满意。80岁及以上患者CLEI的血运重建是合适的,并且能使大多数患者维持独立生活。