Pashos C L, Newhouse J P, McNeil B J
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115.
JAMA. 1993 Oct 20;270(15):1832-6.
To investigate changes between 1987 and 1990 in the care and outcomes associated with acute myocardial infarction (AMI) in elderly patients.
Retrospective cohort study using a longitudinal database created from Medicare administrative files.
Cohorts comprising a total of 856,847 AMI patients insured by Medicare between 1987 and 1990.
Annual rates of mortality at 30 days and 1 year following AMI, and the use of coronary angiography, coronary artery bypass graft surgery, and percutaneous transluminal coronary angioplasty during the first 90 days after a new AMI.
Between 1987 and 1990, mortality rates decreased 10% overall from 26% to 23% at 30 days (P < .001) and from 40% to 36% at 1 year following AMI (P < .001). Declines in mortality and adjusted risks of 1-year mortality were similar in men and women and in blacks and whites, but mortality declines were more evident in those younger than 85 years. Meanwhile, the proportion of elderly AMI patients having angiography within the first 90 days after their index admission increased from 24% to 33% (P < .001); proportions increased for both genders and all races. The proportion of patients undergoing revascularization procedures increased from 13% to 21%; while rates of bypass surgery increased from 8% to 11%, rates of angioplasty doubled from 5% to 10% (all P < .001).
Between 1987 and 1990, survival of elderly patients following AMI improved significantly. While changes in patient treatment may be responsible, the increased use of thrombolytic therapy appears to be only a partial explanation. Also, while the use of coronary angiography and revascularization procedures increased dramatically, the degree to which it caused the improvement in survival could not be determined.
调查1987年至1990年间老年急性心肌梗死(AMI)患者的治疗情况及预后变化。
利用医疗保险管理档案建立的纵向数据库进行回顾性队列研究。
1987年至1990年间共有856847名由医疗保险承保的AMI患者组成队列。
AMI后30天和1年的年死亡率,以及新发AMI后前90天内冠状动脉造影、冠状动脉搭桥手术和经皮腔内冠状动脉成形术的使用情况。
1987年至1990年间,AMI后30天的死亡率总体下降10%,从26%降至23%(P<.001),1年后从40%降至36%(P<.001)。男性和女性、黑人和白人的死亡率及1年死亡率的调整风险下降相似,但85岁以下患者的死亡率下降更为明显。同时,老年AMI患者在首次入院后前90天内进行血管造影的比例从24%增至33%(P<.001);各性别和所有种族的比例均增加。接受血运重建手术的患者比例从13%增至21%;搭桥手术率从8%增至11%,血管成形术率从5%翻倍至10%(均P<.001)。
1987年至1990年间,老年AMI患者的生存率显著提高。虽然患者治疗的变化可能是原因,但溶栓治疗使用的增加似乎只是部分解释。此外,虽然冠状动脉造影和血运重建手术的使用显著增加,但无法确定其对生存率提高的影响程度。