Saito T, Shimoda K, Kinoshita T, Shigemitsu Y, Miyahara M, Nakamura A, Kobayashi M
First Department of Surgery, Oita Medical University.
Jpn J Clin Oncol. 1993 Aug;23(4):238-45.
To evaluate the risk of transthoracic esophagectomy for cancer based on the overall impairment of vital organs, we examined pulmonary, cardiac, renal and hepatic functions using 18 markers in 35 patients between 1982 and 1984. A discriminant analysis proved useful in determining whether or not the patients would be at risk of operative mortality (operative death and hospital death), based on the overall impairment of vital organs. The accuracy of the prediction of operative mortality by this model, the organ function index (OFI), was 91.4%. The OFI was then applied to 66 patients seen between 1986 and 1991. During this period, a change in policy for performing transthoracic esophagectomy and perioperative care on patients with impairment of multiple organs was associated with a decrease in operative mortality. We conclude the OFI to be beneficial in evaluating the risk of operative mortality based on mild to moderate dysfunctions of multiple vital organs in patients with esophageal cancer.
为了基于重要器官的整体损害评估经胸食管癌切除术的风险，我们在1982年至1984年间，使用18项指标对35例患者的肺、心脏、肾脏和肝脏功能进行了检查。判别分析被证明有助于根据重要器官的整体损害来确定患者是否有手术死亡风险（手术死亡和医院死亡）。该模型（器官功能指数，OFI）对手术死亡率预测的准确率为91.4%。然后将OFI应用于1986年至1991年间的66例患者。在此期间，对多器官损害患者进行经胸食管癌切除术和围手术期护理的政策变化与手术死亡率的降低相关。我们得出结论，OFI有助于基于食管癌患者多个重要器官的轻至中度功能障碍评估手术死亡风险。
