Bida S A, Dennis S M
Res Vet Sci. 1977 Jan;22(1):18-22.
Differences in histopathological changes between experimentally and naturally induced dermatophilosis were slight; natural infections persisted longer as they tended to be complicated by other concurrent dermatoses. Sequential pathological changes in bovine dermatophilosis included congestion, dermal oedema and neutrophilic infiltration of dermal papilae and epidermis by the third day; degenerative changes of cells in the upper portion of the stratum spinosum and invasion of the keratinised layer and hair follicles by the filamentous forms of Dermatophilus congolensis by the fourth day; regenerative processes involving the basal cells and selective cellular destruction in the spinous layer and further hair follicle invasion by D congolensis by the ninth day; and proliferative changes characterised by parakeratosis, hyperkeratosis, acanthosis and dermal sclerosis by the 15th day. It is postulated that cattle with hair follicles parasitised by D congolensis are carriers and are responsible for perpetuation of bovine dermatophilosis from one season to the next.
实验性诱导和自然诱导的皮肤嗜皮菌病在组织病理学变化上差异微小；自然感染持续时间更长，因为它们往往会并发其他皮肤病。牛皮肤嗜皮菌病的连续病理变化包括：到第三天时出现充血、真皮水肿以及真皮乳头和表皮的嗜中性粒细胞浸润；到第四天时棘层上部细胞出现退行性变化，刚果嗜皮菌的丝状形态侵入角质层和毛囊；到第九天涉及基底细胞的再生过程以及棘层中的选择性细胞破坏，刚果嗜皮菌进一步侵入毛囊；到第15天出现以不全角化、角化过度、棘层肥厚和真皮硬化为特征的增殖性变化。据推测，毛囊被刚果嗜皮菌寄生的牛是携带者，并且是牛皮肤嗜皮菌病从一个季节延续到下一个季节的原因。
