Malin D H, Lake J R, Arcangeli K R, Deshotel K D, Hausam D D, Witherspoon W E, Carter V A, Yang H Y, Pal B, Burgess K
Univ. of Houston, Clear Lake, TX 77058.
Life Sci. 1993;53(17):PL261-6. doi: 10.1016/0024-3205(93)90601-x.
Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls.
神经肽FF（NPFF）已被证明具有多种抗阿片作用，包括通过向吗啡依赖大鼠的第三脑室注射来诱发阿片戒断综合征。在本研究中，将NPFF的亲脂性类似物丹磺酰 - 脯氨酰 - 谷氨酰胺 - 精氨酰 - 苯丙酰胺以9mg/kg皮下注射给吗啡依赖大鼠和适当的假手术对照组。比较组仅注射乙醇/水载体。NPFF类似物在吗啡依赖大鼠中诱发了强烈的阿片戒断综合征，但在假手术对照组中未诱发。
