编码Ca2+/钙调蛋白依赖性蛋白激酶IVβ多肽的基因的克隆与测序及其在成熟小脑颗粒细胞中的特异性表达。
Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells.
作者信息
Sakagami H, Kondo H
机构信息
Department of Anatomy, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Brain Res Mol Brain Res. 1993 Aug;19(3):215-8. doi: 10.1016/0169-328x(93)90029-o.
PMID:8412563
Abstract
A cDNA encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV) was isolated and sequenced from a rat cerebellar cDNA library. By in situ hybridization histochemistry, we demonstrated the differential gene expression for alpha and beta polypeptides of CaM kinase IV in mature and developing rat brains using oligonucleotide probes specific for each polypeptide.
摘要
从大鼠小脑cDNA文库中分离并测序了编码钙调蛋白依赖性蛋白激酶IV（CaM激酶IV）β多肽的cDNA。通过原位杂交组织化学，我们使用针对每种多肽的寡核苷酸探针，证明了CaM激酶IV的α和β多肽在成熟和发育中的大鼠脑中的差异基因表达。
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