Weber T H, Knuutila S, Tammisto P, Tontti K
Scand J Haematol. 1977 Feb;18(2):81-5. doi: 10.1111/j.1600-0609.1977.tb02075.x.
Patients treated when phenytoin for periods of several months or years have slightly, but significantly lower whole blood and red cell folate values than comparable controls. This holds true irrespective of whether folate is determined microbiologically with Lactobacillus casei or by a radioligand method using the bovine milk binder. Haematological parameters including Hb, MCH, MCV and red blood cell counts did not show any alterations and no patient developed any signs of anaemia. This indicates that long-term use of phenytoin does not cause a clinically significant state of folate deficiency, unless some other contributing factors are present.
接受苯妥英治疗数月或数年的患者，其全血和红细胞叶酸值略低于但显著低于可比对照组。无论叶酸是通过用干酪乳杆菌进行微生物学测定，还是通过使用牛乳结合剂的放射性配体方法测定，都是如此。包括血红蛋白（Hb）、平均红细胞血红蛋白含量（MCH）、平均红细胞体积（MCV）和红细胞计数在内的血液学参数没有任何变化，且没有患者出现任何贫血迹象。这表明，长期使用苯妥英不会导致临床上显著的叶酸缺乏状态，除非存在其他一些促成因素。
