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Meizothrombin: active intermediate formed during prothrombinase-catalyzed activation of prothrombin.

作者信息

Doyle M F, Haley P E

机构信息

Haematologic Technologies, Inc., Essex Junction, Vermont 05452.

出版信息

Methods Enzymol. 1993;222:299-312. doi: 10.1016/0076-6879(93)22020-g.

DOI:10.1016/0076-6879(93)22020-g
PMID:8412800
Abstract
摘要

相似文献

1
Meizothrombin: active intermediate formed during prothrombinase-catalyzed activation of prothrombin.中间凝血酶：在凝血酶原酶催化凝血酶原激活过程中形成的活性中间体。
Methods Enzymol. 1993;222:299-312. doi: 10.1016/0076-6879(93)22020-g.
2
The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction.凝血酶原酶催化凝血酶原的激活在一个有序的顺序反应中通过中间产物中凝血酶进行。
J Biol Chem. 1986 Jul 5;261(19):8977-84.
3
Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.人凝血酶原酶对人凝血酶原的激活。因子Va对反应机制的影响。
J Biol Chem. 1987 Mar 5;262(7):3291-9.
4
Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.凝血因子Va重链酸性水蛭素样COOH末端氨基酸区域在凝血酶原酶功能增强中的作用。
Biochemistry. 2008 Jul 29;47(30):7963-74. doi: 10.1021/bi800593k. Epub 2008 Jul 1.
5
The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase.凝血酶原片段1与膜表面的相互作用是凝血酶原酶中因子Va辅因子活性最佳表达的先决条件。
Thromb Haemost. 2008 Mar;99(3):511-22.
6
The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis.凝血酶原酶复合物对凝血酶原的激活。底物-膜相互作用对催化作用的贡献。
J Biol Chem. 1994 Nov 4;269(44):27441-50.
7
Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites.外部位点结合将大分子底物拴系到凝血酶原酶复合物上，并指导在两个空间上不同的位点进行切割。
J Biol Chem. 2000 Dec 8;275(49):38561-70. doi: 10.1074/jbc.M006637200.
8
Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma.凝血因子Xa催化凝血酶原激活过程中中间凝血酶的形成。在纯化系统和血浆中的形成。
J Biol Chem. 1991 Nov 15;266(32):21864-73.
9
Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin.原位生成的凝血酶原激活产物在内皮细胞上激活蛋白C：中间凝血酶比α-凝血酶是更好的蛋白C激活剂。
Biochem J. 1996 Oct 15;319 ( Pt 2)(Pt 2):399-405. doi: 10.1042/bj3190399.
10
Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase .重链氨基酸区域 659-663 对凝血酶原酶中因子 Xa 活性的贡献。
Biochemistry. 2010 Oct 5;49(39):8520-34. doi: 10.1021/bi101097t. Epub 2010 Sep 13.

引用本文的文献

1
Spellbinding Effects of the Acidic COOH-Terminus of Factor Va Heavy Chain on Prothrombinase Activity and Function.凝血因子Va重链酸性COOH末端对凝血酶原酶活性和功能的迷人作用。
ACS Omega. 2017 Sep 30;2(9):5529-5537. doi: 10.1021/acsomega.7b00769. Epub 2017 Sep 6.
2
The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.凝血酶原的片段1区域促进片段12与酶原的优先结合，并赋予蛋白酶类似酶原的特性。
J Biol Chem. 2016 May 20;291(21):11114-23. doi: 10.1074/jbc.M116.723072. Epub 2016 Mar 24.
3
The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin.
凝血酶原中亮氨酸480和谷氨酰胺481氨基酸的双重调节作用
J Biol Chem. 2016 Jan 22;291(4):1565-1581. doi: 10.1074/jbc.M115.691956. Epub 2015 Nov 24.
4
Viscoelasticity and Ultrastructure in Coagulation and Inflammation: Two Diverse Techniques, One Conclusion.凝血与炎症中的粘弹性和超微结构：两种不同技术，一个结论。
Inflammation. 2015 Aug;38(4):1707-26. doi: 10.1007/s10753-015-0148-7.
5
The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells.镰状细胞病中红细胞对凝血酶生成的贡献：镰状红细胞上中凝血酶的生成。
J Thromb Haemost. 2013 Dec;11(12):2187-9. doi: 10.1111/jth.12423.
6
Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage.凝血酶原与膜的结合介导了其向凝血酶原酶的受限呈递以进行裂解。
J Biol Chem. 2013 Sep 27;288(39):27789-800. doi: 10.1074/jbc.M113.502005. Epub 2013 Aug 12.
7
Meizothrombin is an unexpectedly zymogen-like variant of thrombin.美泽血栓素是一种出乎意料的类酶原变体的凝血酶。
J Biol Chem. 2012 Aug 31;287(36):30414-25. doi: 10.1074/jbc.M112.394809. Epub 2012 Jul 19.
8
Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase .重链氨基酸区域 659-663 对凝血酶原酶中因子 Xa 活性的贡献。
Biochemistry. 2010 Oct 5;49(39):8520-34. doi: 10.1021/bi101097t. Epub 2010 Sep 13.
9
Cooperative regulation of the activity of factor Xa within prothrombinase by discrete amino acid regions from factor Va heavy chain.凝血因子Va重链中离散氨基酸区域对凝血酶原酶中因子Xa活性的协同调节。
Biochemistry. 2008 Dec 2;47(48):12835-43. doi: 10.1021/bi801241r.
10
Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.凝血酶原酶激活人凝血酶原过程中膜结合反应物和产物的命运
J Biol Chem. 2008 Oct 31;283(44):30164-73. doi: 10.1074/jbc.M806158200. Epub 2008 Sep 2.