Ye G F, Moore T W, Jaron D
Biomedical Engineering and Science Institute, Drexel University, Philadelphia, Pennsylvania 19104.
Microvasc Res. 1993 Jul;46(1):1-18. doi: 10.1006/mvre.1993.1031.
We previously derived a compartmental model for oxygen transport in vascular blood in which lumped terms, representing convective and oxygen dissociative effects, were obtained from a distributed model by space averaging. In this paper, we compare the results of this model and those of another compartmental model from the literature in which these terms were selected arbitrarily. The use of space-averaged parameters resulted in a more distinct difference in calculated partial pressures of oxygen between capillary and venule compartments, more accurate distribution patterns for partial pressures of oxygen through the venule compartments, and a capability to simulate conditions under which mean oxygen partial pressure in tissue is higher than in the venules. These results are supported by available experimental findings. Results also showed that the employment of space-averaged convective terms had a greater effect on the distribution of compartmental partial pressures than did the use of the cross-sectional averaged oxygen-hemoglobin binding function. The latter produced significant changes only for certain compartments, and only under extreme physiologic conditions. The results demonstrate our model's ability to reflect relationships among capillary, venule, and tissue compartmental partial pressures under varying conditions.
我们之前推导了一个用于血管血液中氧气运输的房室模型，其中代表对流和氧离解效应的集总项是通过空间平均从分布式模型中获得的。在本文中，我们将该模型的结果与文献中另一个房室模型的结果进行比较，在另一个模型中这些项是任意选择的。使用空间平均参数导致毛细血管和小静脉房室之间计算出的氧分压有更明显的差异，小静脉房室中氧分压的分布模式更准确，并且能够模拟组织中平均氧分压高于小静脉的情况。这些结果得到了现有实验结果的支持。结果还表明，与使用横截面平均氧合血红蛋白结合函数相比，采用空间平均对流项对房室分压分布的影响更大。后者仅在某些房室中产生显著变化，并且仅在极端生理条件下。结果证明了我们的模型能够反映不同条件下毛细血管、小静脉和组织房室分压之间的关系。
