Zasadny K R, Koral K F, Swailem F M
Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor.
Med Phys. 1993 Jul-Aug;20(4):1115-20. doi: 10.1118/1.597008.
Two side-by-side energy windows are sometimes employed in quantitative single photon emission computed tomography (SPECT) studies. The count-rate losses at high activities for a GE400AT camera were measured in such a dual-window-acquisition mode by imaging a decaying source composed of a hot sphere within a warm cylinder. The data in each window was either kept separate or combined for purposes of dead-time correction and the paralyzable model was assumed. In addition, correction factors were derived from a "monitor" source at the edge of the camera. Finally, energy spectra for only the monitor-source region of interest and for the entire camera were obtained under both low- and high-count conditions and compared. With 99mTc (1) the spectral measurements show no peak shift but reveal pulse-pile-up spectral degradation. (2) The monitor-source corrections do not agree well with those from the model, presumably because of the differential effects of such degradation. For this camera the preferred correction method for patients is one using the model and two, effective, phantom-derived dead times for the separate data from the two windows. The two effective dead times are needed to compensate for pulse pile-up adding more counts to the lower-energy window than to the higher-energy one at high rates.(ABSTRACT TRUNCATED AT 250 WORDS)
在定量单光子发射计算机断层扫描(SPECT)研究中,有时会采用两个并排的能量窗。通过对一个由置于温圆柱体中的热球体组成的衰减源进行成像,以双窗采集模式测量了GE400AT相机在高活度下的计数率损失。为了进行死时间校正,每个窗中的数据要么保持分开,要么合并,并假定采用可麻痹模型。此外,校正因子是从相机边缘的一个“监测”源得出的。最后,在低计数和高计数条件下均获取了仅针对监测源感兴趣区域以及整个相机的能谱,并进行了比较。对于99mTc:(1)能谱测量未显示峰位移动,但揭示了脉冲堆积导致的能谱退化。(2)监测源校正与模型校正结果不太一致,可能是由于这种退化的差异效应。对于此相机,针对患者的首选校正方法是一种使用模型的方法,以及针对来自两个窗的单独数据的两个有效的、源自体模的死时间。需要这两个有效的死时间来补偿脉冲堆积,在高计数率下,脉冲堆积会给低能窗添加比高能窗更多的计数。(摘要截短于250字)