Dickmann Z, Gupta J S, Dey S K
Science. 1977 Feb 18;195(4279):687-8. doi: 10.1126/science.841306.
Fertilized eggs were incubated for 2 hours in a medium containing estradiol-17beta and then transferred into the uteri of day 5 pseudopregnant rats. These eggs, but not estrogen-free control eggs, induced a local increase in capillary permeability. We suggest that the blastocyst factor which induces the local increase in capillary permeability during early pregnancy is estrogen synthesized by the blastocyst.
将受精卵在含有17β-雌二醇的培养基中孵育2小时，然后移植到第5天假孕大鼠的子宫中。这些卵，而非不含雌激素的对照卵，可引起局部毛细血管通透性增加。我们认为，在妊娠早期诱导局部毛细血管通透性增加的囊胚因子是由囊胚合成的雌激素。
