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[血红蛋白SD病]

[Hemoglobin SD disease].

作者信息

Laws H J, Dickerhoff R, Mayer J, Köster B

机构信息

Zentrum für Kinder- und Jugendmedizin, Kreiskrankenhaus Lüdenscheid.

出版信息

Monatsschr Kinderheilkd. 1993 Sep;141(9):708-10.

PMID:8413345
Abstract

A 7 year old Kurdish girl presented with a cerebral infarction and a resulting hemiparesis following a blood transfusion. Examination of the blood film suggested sickle cell anaemia. However a simultaneously carried out haemoglobin electrophoresis showed haemoglobin S and haemoglobin D. The diagnosis of haemoglobin SD disease was thereby established. This kind of haemoglobin disorder usually shows a mild clinical manifestation. According to our knowledge such serious cases have not been published before. With this disease the main emphasis is on the prevention of recurrent cerebral infarctions bay a long-term transfusion programme whereas the effects of the cerebral infarction are treated in the usual way.

摘要

一名7岁的库尔德女孩在输血后出现脑梗死并导致偏瘫。血涂片检查提示镰状细胞贫血。然而,同时进行的血红蛋白电泳显示有血红蛋白S和血红蛋白D。由此确诊为血红蛋白SD病。这种血红蛋白疾病通常临床表现较轻。据我们所知,此前尚未有此类严重病例的报道。对于这种疾病,主要重点是通过长期输血方案预防复发性脑梗死,而脑梗死的影响则按常规方法治疗。

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