Leppert D, Wieser H G
Neurologische Klinik, Universitätsspital Zürich.
Nervenarzt. 1993 Aug;64(8):494-503.
Epilepsy is the most common neurological disease of females in reproductive age. Problems concerning contraception, reproduction, teratogenicity and antiepileptic therapy preceding and during pregnancy are discussed and recommendations made. We underline the advantages of a planned pregnancy with optimal adjustment of antiepileptic drug therapy and recommend prophylactic treatment with folic acid before and during, and with vitamin K towards the end of pregnancy.
癫痫是育龄女性中最常见的神经系统疾病。文中讨论了与避孕、生育、致畸性以及妊娠前后抗癫痫治疗相关的问题，并给出了建议。我们强调计划妊娠并优化调整抗癫痫药物治疗的优势，建议在妊娠前和妊娠期间补充叶酸进行预防性治疗，并在妊娠晚期补充维生素K。
