Tateyama M, Ohta S, Nagao T, Hirobe M, Ono H
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Neuropharmacology. 1993 Aug;32(8):761-6. doi: 10.1016/0028-3908(93)90184-5.
The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measured by the brain microdialysis method. 4-PTIQ hydrochloride (20 micrograms) co-injected with methamphetamine inhibited both the increase in dopamine and the locomotor activity. The uptake blocker cocaine hydrochloride (20 micrograms) co-injected with methamphetamine failed to inhibit the effect of methamphetamine. Thus 4-PTIQ but not cocaine inhibited the dopamine-releasing effect of methamphetamine, and 4-PTIQ is suggested to block methamphetamine-induced locomotion by inhibition of dopamine release.
研究了4-苯基-1,2,3,4-四氢异喹啉（4-PTIQ）对甲基苯丙胺诱导的多巴胺增加和运动的抑制作用。通过脑微透析法测量，向伏隔核微量注射盐酸甲基苯丙胺（10微克）可增加运动活性和细胞外多巴胺水平。与甲基苯丙胺共同注射的盐酸4-PTIQ（20微克）可抑制多巴胺增加和运动活性。与甲基苯丙胺共同注射的摄取阻断剂盐酸可卡因（20微克）未能抑制甲基苯丙胺的作用。因此，4-PTIQ而非可卡因抑制了甲基苯丙胺的多巴胺释放作用，并且提示4-PTIQ通过抑制多巴胺释放来阻断甲基苯丙胺诱导的运动。
