Barone D, Coccia G, Marziano C, Tricerri R, Bonelli L, Tomassini E, Bistolfi F
Radiotherapy Department, Galliera Hospital, Genoa, Italy.
Panminerva Med. 1993 Jun;35(2):86-92.
Twenty eight patients with previously untreated oesophageal carcinoma without distant metastases were divided into two groups: Group A consisted of 18 pts. treated with conventional external radiotherapy only. Another group of 10 pts. (Group B) received treatment with external beam irradiation with further high dose rate intraluminal brachytherapy up to a dose of 4-12 Gy delivered in 2-3 sessions of 4 Gy (one session a week). All pts. were evaluated clinically, radiologically and endoscopically every 3 months. At the end of treatment there was a marked difference in relief of dysphagia (39% in Group A vs. 90% in Group B), local control (56.7% in Group A vs. 100% in Group B) and time to progression of dysphagia (20.8 weeks in Group A vs. 67.7 weeks in Group B). No marked difference was observed in overall survival. The complication rate was low in both groups and major complications were observed in pts. treated with external radiotherapy alone (two fistulas). The association of external beam and intraluminal radiotherapy can give a better local control of the disease, improving the quality of life.
28例既往未接受过治疗且无远处转移的食管癌患者被分为两组：A组由18例仅接受传统外照射放疗的患者组成。另一组10例患者（B组）接受外照射放疗联合高剂量率腔内近距离放疗，剂量为4 - 12 Gy，分2 - 3次给予，每次4 Gy（每周1次）。所有患者每3个月进行一次临床、影像学和内镜评估。治疗结束时，两组在吞咽困难缓解情况（A组为39%，B组为90%）、局部控制情况（A组为56.7%，B组为100%）以及吞咽困难进展时间（A组为20.8周，B组为67.7周）方面存在显著差异。总生存率方面未观察到显著差异。两组并发症发生率均较低，仅接受外照射放疗的患者出现了严重并发症（2例瘘管）。外照射与腔内放疗联合应用可更好地实现疾病的局部控制，提高生活质量。
