Witten M L, McKee J L, Lantz R C, Hays A M, Quan S F, Sobonya R E, Lemen R J
Department of Pediatrics, University of Arizona College of Medicine, Tucson.
Pediatr Pulmonol. 1993 Jul;16(1):62-8. doi: 10.1002/ppul.1950160113.
Acute viral respiratory infections are commonly associated with alteration in lung growth and with chronic obstructive disease. However, it is difficult to quantify these changes in lung function. We determined that the recently described techniques of fractal analysis gave additional information about the changes in lung function after viral illness compared to standard morphometric techniques. Fractal and morphometric parameters change with lung growth after acute infection with canine adenovirus type 2 (CAV2, n = 5) or no infection (controls, n = 6) in beagle puppies. Lung pathological studies showed areas of obliterative bronchiolitis and chronic small airways inflammation but no emphysema in the CAV2-infected puppies. Morphometric studies at approximately 236 days of age demonstrated accelerated lung growth in the CAV2-infected dogs as evidenced by significant increases in lung volume (VL) and internal surface area (ISA). Fractal analysis showed an increased fractal dimension (Df) of the alveolar perimeter length in the CAV2 group associated with increased growth that was similar to the percentage change in VL and ISA. These data suggest that a single infection with CAV2 in beagle puppies accelerates lung growth and increases the complexity (Df) of the alveolar structure.
急性病毒性呼吸道感染通常与肺生长改变及慢性阻塞性疾病相关。然而，很难对肺功能的这些变化进行量化。我们确定，与标准形态测量技术相比，最近描述的分形分析技术能提供有关病毒感染后肺功能变化的更多信息。在比格幼犬中，感染犬2型腺病毒（CAV2，n = 5）或未感染（对照组，n = 6）后，分形和形态测量参数随肺生长而变化。肺病理学研究显示，CAV2感染的幼犬存在闭塞性细支气管炎和慢性小气道炎症区域，但无肺气肿。约236日龄时的形态测量研究表明，CAV2感染犬的肺生长加速，肺容积（VL）和内表面积（ISA）显著增加即证明了这一点。分形分析显示，CAV2组肺泡周长的分形维数（Df）增加，与生长增加相关，这与VL和ISA的百分比变化相似。这些数据表明，比格幼犬单次感染CAV2会加速肺生长并增加肺泡结构的复杂性（Df）。
