Bramson R T, Meyer T L, Silbiger M L, Blickman J G, Halpern E
Department of Radiology, University of South Florida College of Medicine, Tampa General Hospital.
Pediatrics. 1993 Oct;92(4):524-6.
Major pediatric textbooks advocate a chest radiograph as part of the diagnostic evaluation for a sepsis workup for febrile infants less than 3 months old. Very few studies have addressed the value of performing a chest radiograph in this situation. Two studies previously published lack the numbers to statistically justify a conclusion about the need to perform a chest radiograph in the febrile infant.
Evaluated were 197 febrile infants 3 months old or less with a history, physical examination, chest radiograph, and other laboratory studies to determine the cause of their fever. This group of infants was combined with the group of infants from two similar studies published previously in the literature using cumulative meta-analysis. The combined group resulted in 617 infants.
The combined group of infants had 361 infants who had no clinical evidence of pulmonary disease on history or physical examination. All 361 infants had normal chest radiograph. These results gave a 95% confidence interval that the chance of a positive chest radiograph in a patient with no pulmonary symptoms would occur less than 1.02% of the time.
The generally advocated policy of obtaining a chest radiograph as part of the sepsis workup in febrile infants should be discontinued, and chest radiographs should be obtained only in febrile infants who have clinical indications of pulmonary disease.
主要的儿科教科书提倡对3个月以下发热婴儿进行脓毒症检查时,胸部X光检查应作为诊断评估的一部分。很少有研究探讨在这种情况下进行胸部X光检查的价值。之前发表的两项研究因样本数量不足,无法从统计学上证明对发热婴儿进行胸部X光检查的必要性。
对197名3个月及以下的发热婴儿进行评估,通过病史、体格检查、胸部X光检查及其他实验室检查来确定其发热原因。将这组婴儿与之前文献中发表的两项类似研究中的婴儿组进行累积荟萃分析。合并后的组共有617名婴儿。
合并后的婴儿组中有361名婴儿在病史或体格检查中无肺部疾病的临床证据。所有361名婴儿的胸部X光检查结果均正常。这些结果给出了95%的置信区间,即无肺部症状患者胸部X光检查呈阳性的几率在1.02%以下。
在发热婴儿脓毒症检查中普遍提倡的进行胸部X光检查的政策应停止,仅应对有肺部疾病临床指征的发热婴儿进行胸部X光检查。