Silberbach G M, Imus R L, McDonald R W, Andrilenas K, Rice M J, Reller M D
Division of Pediatric Cardiology, Oregon Health Sciences University, Portland 97201.
Pediatr Cardiol. 1993 Jul;14(3):155-8. doi: 10.1007/BF00795644.
Right ventricular systolic time intervals (RVSTI) and noninvasive Doppler-derived pulmonary blood flow were measured before and after surgical ductus ligation in 18 otherwise healthy infants and children who were older than 3 months of age. Right ventricular preejection period (PEP) and the ratio of preejection period and right ventricular ejection time (PEP/RVET), both corrected or uncorrected for heart rate, decreased significantly following surgery (PEP 71 +/- 14 vs. 50 +/- 13, p < 0.001 and PEP/RVET 0.29 +/- 0.06 vs. 0.21 +/- 0.05, p < 0.001). The volume of pulmonary blood flow correlated with PEP/RVET (r = 0.48, p = 0.003). The magnitude of the change in pulmonary blood flow correlated with the change in PEP/RVET (r divided by 0.56, p = 0.016). The velocity of circumferential fiber shortening (VCFc) increased after surgery, but not significantly. We speculate that patent ductus arteriosus has a similar effect on right ventricular performance when other congenital heart defects are present.
在18名年龄大于3个月的健康婴幼儿中，于手术结扎动脉导管前后测量右心室收缩时间间期（RVSTI）及无创多普勒衍生的肺血流量。右心室射血前期（PEP）以及射血前期与右心室射血时间的比值（PEP/RVET），无论是否校正心率，术后均显著降低（PEP：71±14对比50±13，p<0.001；PEP/RVET：0.29±0.06对比0.21±0.05，p<0.001）。肺血流量与PEP/RVET相关（r=0.48，p=0.003）。肺血流量变化的幅度与PEP/RVET的变化相关（r=0.56，p=0.016）。术后圆周纤维缩短速度（VCFc）增加，但无显著差异。我们推测，当存在其他先天性心脏缺陷时，动脉导管未闭对右心室功能有类似影响。
