Cohen P R, Hebert A A, Adler-Storthz K
Department of Dermatology, University of Texas Medical School at Houston 77030.
Pediatr Dermatol. 1993 Sep;10(3):245-51. doi: 10.1111/j.1525-1470.1993.tb00369.x.
Two sisters of Mexican ancestry had focal epithelial hyperplasia (FEH). The lesions on the oral mucosa of the older child were initially misinterpreted as representing sexual abuse. Microscopic evaluation of a hematoxylin and eosin-stained section from a lower lip papule demonstrated the histologic features of FEH. Although human papillomavirus (HPV) type 13 and HPV32 have been most consistently present in FEH lesions, types 6, 11, 13, and 32 were not detected in the paraffin-embedded tissue specimen of our patient using an in situ hybridization technique. The lesions persisted or recurred during management using destructive modalities; subsequently, they completely resolved spontaneously.
两名有墨西哥血统的姐妹患有局灶性上皮增生（FEH）。年长儿童口腔黏膜上的病变最初被误诊为性虐待。对下唇丘疹苏木精和伊红染色切片进行显微镜评估，显示出FEH的组织学特征。尽管13型人乳头瘤病毒（HPV）和32型HPV在FEH病变中最为常见，但使用原位杂交技术在我们患者的石蜡包埋组织标本中未检测到6型、11型、13型和32型HPV。在使用破坏性方法治疗期间，病变持续存在或复发；随后，它们自行完全消退。
