Hicks M J, Levy M L, Alexander J, Flaitz C M
Department of Pathology, Texas Children's Hospital, Houston 77030.
Pediatr Dermatol. 1993 Sep;10(3):271-6. doi: 10.1111/j.1525-1470.1993.tb00375.x.
Subcutaneous fat necrosis of the newborn (SCFN) alone is an uncommon condition. Its association with hypercalcemia has been reported in 19 neonates since 1926. The two occur in full-term to postterm newborns with perinatal complications associated with delivery. Erythematous to violaceous, firm, subcutaneous nodules appear approximately 1 to 4 weeks after delivery, preceding the development of signs and symptoms of hypercalcemia. Although SCFN and hypercalcemia are rare complications in neonates with perinatal problems, death due to the sequelae of hypercalcemia occurred in 3 of the 19 patients. A neonate who develops skin lesions consistent with SCFN should be followed for possible onset of hypercalcemia and treated in a timely fashion.
单纯性新生儿皮下脂肪坏死（SCFN）是一种罕见病症。自1926年以来，已有19例新生儿被报道患有此病并伴有高钙血症。二者均发生于足月儿至过期产儿，且伴有与分娩相关的围产期并发症。分娩后约1至4周，会出现从红斑到紫蓝色、质地坚硬的皮下结节，随后才出现高钙血症的体征和症状。尽管SCFN和高钙血症在有围产期问题的新生儿中是罕见并发症，但19例患者中有3例因高钙血症后遗症死亡。出现与SCFN相符的皮肤病变的新生儿应密切观察是否可能出现高钙血症，并及时进行治疗。
