Samedi Veronica Mugarab, Yusuf Kamran, Yee Wendy, Obaid Hala, Al Awad Essa Hamdan
Section of Neonatology, Peter Lougheed Centre, Calgary, Alberta, Canada ; Section of Neonatology, University of Calgary, Calgary, Alberta, Canada.
Section of Neonatology, University of Calgary, Calgary, Alberta, Canada.
AJP Rep. 2014 Nov;4(2):e93-6. doi: 10.1055/s-0034-1395987. Epub 2014 Nov 19.
Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few published case reports of SCFN, following this modality of treatment. Although, most cases of SCFN resolve spontaneously, SCFN may be associated with hypercalcemia, which may sometimes reach dangerous levels. Approaches used for the management of this potentially life-threatening condition, include hyperhydration, calciuric diuretics, corticosteroids, and in more resistant cases pamidronate, a bisphosphonate. We report our experience on the use of pamidronate in two cases of severe hypercalcemia associated with SCFN following therapeutic hypothermia for HIE. We believe that with increasing use of therapeutic hypothermia for HIE, clinicians are likely to encounter this condition more frequently.
皮下脂肪坏死（SCFN）是一种非感染性脂膜炎，发生于足月新生儿，这些新生儿在出生后第一周经历严重窘迫，包括缺氧缺血性脑病（HIE）。自从将亚低温疗法用于治疗HIE以来，已有一些关于采用这种治疗方式后发生SCFN的病例报告发表。虽然大多数SCFN病例可自行消退，但SCFN可能与高钙血症有关，高钙血症有时可能达到危险水平。用于管理这种潜在危及生命状况的方法包括补液、促钙尿利尿剂、皮质类固醇，在更难治的病例中使用双膦酸盐帕米膦酸。我们报告了在两例HIE亚低温治疗后发生的与SCFN相关的严重高钙血症病例中使用帕米膦酸的经验。我们认为，随着HIE亚低温疗法使用的增加，临床医生可能会更频繁地遇到这种情况。
