[Molecular and cellular aspects of cis-diamminedichloroplatinum (II) interactions with DNA].

Cis-DDP is an antitumor drug with activity against various human tumors. It is generally accepted that DNA is the cellular target of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eukaryotic systems. We also discuss the possible mechanisms of acquired resistance of cancerous cells to cis-DDP and analogues, and potential clinical implication of this phenomenon.