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[Molecular and cellular aspects of cis-diamminedichloroplatinum (II) interactions with DNA].

作者信息

Zastawny T H, Oliński R

机构信息

Zakład Biochemii Klinicznej Akademii Medycznej, Bydgoszczy.

出版信息

Postepy Hig Med Dosw. 1993;47(2):103-23.

PMID:8415320
Abstract

Cis-DDP is an antitumor drug with activity against various human tumors. It is generally accepted that DNA is the cellular target of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eukaryotic systems. We also discuss the possible mechanisms of acquired resistance of cancerous cells to cis-DDP and analogues, and potential clinical implication of this phenomenon.

摘要

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1
[Molecular and cellular aspects of cis-diamminedichloroplatinum (II) interactions with DNA].
Postepy Hig Med Dosw. 1993;47(2):103-23.
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