Terada M, Kino H, Akyol C V, Sano M
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Parasitol Res. 1993;79(6):441-3. doi: 10.1007/BF00931579.
Mebendazole was given to mice infected with Angiostrongylus costaricensis at a single dose of 5 mg/kg at 6, 11, 16 or 21 days post-infection (p.i.) and in five successive doses at 5 mg/kg daily at 6, 11 or 16 days p.i. The effects were comparatively assessed by examining various parameters in host mice and worms. As a whole, the effects of mebendazole were caused more conspicuously by five successive treatments than by a single treatment. In both treatment modalities, the effects were more remarkable in earlier treatments, and nearly complete effects were caused by five successive treatments before 15 days p.i. These results suggest that the inhibition of egg formation and/or oviposition will inhibit the pathological changes caused in the disease by A. costaricensis, especially before the onset of the changes.
给感染哥斯达黎加管圆线虫的小鼠在感染后第6、11、16或21天单剂量给予5 mg/kg甲苯咪唑，以及在感染后第6、11或16天连续5天每天给予5 mg/kg甲苯咪唑。通过检查宿主小鼠和虫体的各种参数对效果进行比较评估。总体而言，甲苯咪唑连续5次给药的效果比单次给药更明显。在两种给药方式中，早期给药的效果更显著，在感染后15天前连续5次给药几乎产生完全效果。这些结果表明，抑制虫卵形成和/或产卵将抑制哥斯达黎加管圆线虫病引起的病理变化，尤其是在变化开始之前。
