Lee K R, Howard P, Heintz N H, Collins C C
Department of Pathology, University of Vermont, College of Medicine, Burlington 05405.
Mod Pathol. 1993 Jul;6(4):433-7.
Using the polymerase chain reaction on paraffin blocks for human papillomavirus (HPV) types 16 and 18, a positive result was seen in three of 20 cases of invasive adenocarcinoma, 15 of 36 cases of adenocarcinoma in-situ, and one of five cases of glandular dysplasia of the uterine cervix. Types 16 and 18 were found with equal frequency. In adenocarcinoma in situ there was no age difference between HPV-positive and or HPV-negative cases. Concomitant squamous dysplasia was slightly more frequent in HPV-positive adenocarcinoma in-situ. HPV positivity rates are lower than most of those previously reported. Possible reasons for this are discussed.
利用聚合酶链反应检测石蜡包埋组织中的人乳头瘤病毒（HPV）16型和18型，结果显示，20例浸润性腺癌中有3例呈阳性，36例原位腺癌中有15例呈阳性，5例子宫颈腺发育异常中有1例呈阳性。16型和18型的检出频率相同。原位腺癌中，HPV阳性和HPV阴性病例之间不存在年龄差异。HPV阳性原位腺癌中伴发鳞状发育异常的情况略为常见。HPV阳性率低于此前大多数报告中的阳性率。文中讨论了造成这种情况的可能原因。
